Chromosome Maps - Genetic Disorders

GENETIC DISORDERS Internet & PowerPoint Project

GENETIC DISORDER CHROMOSOME MAPS

Genetic Disorder Chromosome Maps

Look through the list of genetic disorders found on each chromosome until you locate the one you have been assigned for the project. The disorders in red are the suggested ones for the Genetic Disorders Project. When you have located your genetic disorder, click on the link for the CHROMOSOME # heading. It will link you to the chromosome graphic page to see where the gene causing the disorder is located on the chromosome and copy the chromosome graphic to use in your project.

CHROMOSOME 1 Alzheimer disease, type 4 Gaucher disease Prostate cancer Glaucoma Rh blood type TSH, beta chain Amylase Histone proteins	CHROMOSOME 13 Breast Cancer Retinoblastoma Wilson Disease
CHROMOSOME 2 Antibody, light chain Myosin, light chain Glucagon Mismatch repair 2 (hereditary nonpolyposis colon cancer, type 1, HNPCC) Waardenberg syndrome	CHROMOSOME 14 Ribosomal RNA tRNA proline, leucine, threonine Antibody, heavy chain Alzheimer disease, type 3
CHROMOSOME 3 Rhodopsin (retinitis pigmentosa, partial color blind) Mismatch repair 1 Colon cancer, nonpolyposis, type 2 Small cell lung carcinoma Von Hippel-Lindau syndrome	CHROMOSOME 15 Prader-Willi Syndrome, Angleman Syndrome Tay-Sachs (N-acetyl-hexosaminidase) Marfan syndrome (fibrillin)
CHROMOSOME 4 Alcohol dehydrogenase Red hair color Achondroplasia (dwarfism) Ellis-van Creveld syndrome Huntington disease	CHROMOSOME 16 Hemoglobin, alpha chain Chymotrypsin Polycystic kidney disease
CHROMOSOME 5 Diastrophic dysplasia Steroid 5-alpha-reductase-1 Achondroplasia (dwarfism)	CHROMOSOME 17 p53 Tumor Suppressor Protein Charcot -Marie-Tooth-Syndrome Myosin, heavy chain Neurofibromatosis Collagen 1, alpha 1 (Osteogenesis imperfecta) Growth hormone - Dwarfism Glucose transporter Familial breast & ovarian cancer, type 1
CHROMOSOME 6 MHC (Major Histocompatibility Complex) HCG, FHS, LH, TSH, alpha chain Beta tubulin Juvenile onset diabetes Spinocerebellar atrophy	CHROMOSOME 18 Niemann Pick Disease Pancreatic cancer Suppressor of pancreatic carcinoma ?Tourette Syndrome (may not be this chromosome)
CHROMOSOME 7 Collagen 1, alpha 2 (Osteogenesis imperfecta) Trypsin Blue cone pigment (partial color blind) Cystic fibrosis Obesity	CHROMOSOME 19 Familial hyperchlolesteralemia (LDL receptors) Brown hair color Blue/green eye color LCG, beta chain LH, beta chain (Polio virus sensitivity) Apolipoprotein E Myotonic dystrophy
CHROMOSOME 8 Burkitt lymphoma Werner syndrome	CHROMOSOME 20 Severe combined immunodeficiencydisease (SCID)
CHROMOSOME 9 ABO blood group Ultraviolet repair (xeroderma pigmentosum & skin cancer prone) Malignant melanoma Tuberous sclerosis	CHROMOSOME 21 Ribosomal RNA Amyotrophic lateral sclerosis
CHROMOSOME 10 Hexokinase (hemolytic anemia) Gyrate atrophy of the choroid and retina Multiple endocrine neoplasia	CHROMOSOME 22 Ribosomal RNA Antibody, light chain Myglobin DiGeorge syndrome Neurofibromatosis, type 2
CHROMOSOME 11 Hemoglobin, beta chain (sickle cell anemia, thalessemia) Insulin (mutation NOT usual cause for diabetes) Parathyroid hormone Catalase FHS, beta chain Tyrosinase (Albinism) PAX6, Aniridia Ataxia telangiectasia Harvey ras oncogene Long QT syndrome	CHROMOSOME X Red/green color blindness Hemophilia A Pseudoautosomal region X Interleukin 2 receptor gamma chain (“boy in the bubble”) Adrenoleukodystrophy (ALD-“Lorenzo’s Oil”) Duchenne muscular dystrophy - Becker muscular dystrophy (dystrophin) Menkes syndrome Fragile X (X-linked mental retardation)
CHROMOSOME 12 Tirose phosphate isomerase Keratin Phenylketonuria (PKU) Zellweger syndrome	CHROMOSOME Y Testis-determining factor

(Top of Page)

Chromosome diagrams are from the National Center for Biotechnology Information.
http://www.ncbi.nlm.nih.gov/genome/guide/

(Top of Page)

See Newsweek April 10, 2000 for a great article on the Human Genome Project.
http://newsweek.com/nw-srv/printed/us/st/a18147-2000apr2.htm

(Top of Page)

HUMAN KARYOTYPE IDIOGRAM
Idiograms are similar to karyotypes except they show only 1 set of chromosomes)

Human Idiogram

The idiogram shown is from the National Center for Biotechnology Information.
http://www.ncbi.nlm.nih.gov/genome/guide/

(Top of Page)

Genetic Disorders	Instructions	Storyboard	Web Site Links
Gene Disorder Chromosome Maps	Chromosomal Disorder Karyotypes	Internet Research Tips	Easy PowerPoint

SCOPE PROJECT 2000

Plano ISD - scope@pisd.edu

(Top of Page)